A safe and efficient synthesis of 4,7-dibromo[1,2,5]thiadiazolo[3,4-d]pyridazine from the commercial diaminomaleonitrile is reported.Conditions for selective aromatic nucleophilic substitution seat knob of one or two bromine atoms by oxygen and nitrogen nucleophiles are found, whereas thiols formed the bis-derivatives only.Buchwald-Hartwig or Ullma
Introduction In the last two decades, academic medical centers in the United States have faced a new challenge, dealing with breaches of medical professionalism in their staff, house staff, and medical students.Medical education settings have largely directed PWR REC Loveseat/CON/ADJ HDRST their professionalism efforts toward responding reactively
The article analyses the orientation and priorities of pedagogical communication in the conditions of humanistic paradigm of education.One of the main characteristics of pedagogical communication is the non-violent nature of pedagogical interaction.Frustration Bag in interpersonal relations, emotional distress, insufficient level of professional se
The question of whether mesospheric OH(v) rotational population distributions are in equilibrium with the local kinetic temperature has been debated over several decades.Despite several indications for the existence of non-equilibrium effects, the general consensus has been that emissions originating from low rotational levels are thermalized.Sky s
Porphyromonas gingivalis is a Gram-negative anaerobic bacterium that thrives in the inflamed environment of the gingival crevice, and is strongly associated with periodontal disease.The host response to P.gingivalis requires TLR2, however P.gingivalis benefits from TLR2-driven signaling via activation of PI3K.We studied TLR2 protein-protein interac